Research
Research Database
Our library of research studies and scientific papers substantiating our personalized approach to Braincare.
Trauma Mon. 2015 November
Magnetic Resonance Therapy Improves Clinical Phenotype and EEG AlphaPower in Posttraumatic Stress Disorder
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Elsevier
Synchronized transcranial magnetic stimulation for posttraumaticstress disorder and comorbid major depression
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MHSRS SOC-F
EEG-Guided Transcranial Magnetic Stimulation for the Treatment of Mild Traumatic Brain Injury: A Retrospective Chart...
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MeRT SOCOM USUHS
A Prospective, Double blind, Randomized, Sham-Controlled, Clinical Trial to Evaluate the Safety and Efficacy of Biometrics-guided ...
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Austin Journal of Autism & RelatedDisabilities
The Potential of Magnetic Resonant Therapy in Children with Autism Spectrum Disorder
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Zhi-De Deng, Member, IEEE, and Sarah H. Lisanby
Electric Field Characteristics of Low-Field Synchronized Transcranial Magnetic Stimulation (sTMS)
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Stanford
Low-Field Synchronized Transcranial Magnetic Stimulation (sTMS) for Treatment of Depression: Results from an Open-label Extension Study
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EEG
Transcranial stimulation of alpha oscillations up-regulates the default mode network
Validation of tACS Efficacy (a-tACS Increased Alpha Power and Connectivity)
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Evaluating Robustness of Brain Stimulation Biomarkers for depression: A Systematic Review of MRI and EEG Studies
...baseline and week-1 alpha and theta connectivity (and other features such as power, iAF and cordance), demonstrated high predictive accuracy of response.
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Effects of Rhythmic Transcranial Magnetic Stimulation in the Alpha-Band on Visual Perception Depend on Deviation From Alpha-Peak Frequency: Faster Relative Transcranial Magnetic Stimulation Alpha-Pace Improves Performance
...our secondary analysis showed that IAF was positively correlated with task accuracy across participants
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The relationship between individual alpha peak frequency and clinical outcome with repetitive Transcranial Magnetic Stimulation (rTMS) treatment of Major Depressive Disorder (MDD)
Magnetic Resonance Therapy Improves Clinical Phenotype and EEG AlphaPower in Posttraumatic Stress Disorder
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PTSD
Synchronized transcranial magnetic stimulation for posttraumatic stress disorder and comorbid major depression
All participants demonstrated significant reductions in PTSD and MDD symptoms (all p < .001). As expected, there were significant reductions in symptoms in both treatment groups, but active stimulation did provide greater reductions in count of PTSD moderate-to-severe symptoms
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Pilot Testing of Peak Alpha Frequency Stability During Repetitive Transcranial Magnetic Stimulation
Nicholas J. Petrosino, et al.
Fourteen (66.7%) participants showed meaningful clinical improvement on the PCL-5, and 11 (52.4%) showed a decrease to threshold for categorical PTSD response.
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Posttraumatic Stress Disorder Is Associated with Alpha Dysrhythmia across the Visual Cortex and the Default Mode Network
...simple contrasts of group (PTSD vs controls) revealed (alpha) power deficits in PTSD across the visual and DMN ROIs at each state.
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Alpha oscillations and their impairment in affective and post-traumatic stress disorders
Overall, studies examining alpha power in affective, obsessive-compulsive, and post-traumatic stress disorders underscore the relationship between abnormalities in oscillatory alpha activity and psychopathology.
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Depression
The relationship between brain oscillatory activity and therapeutic effectiveness of transcranial magnetic stimulation in the treatment of major depressive disorder
Andrew F.Leuchter, et al.
Administration of alpha frequency rTMS that is synchronized to the patient’s IAF should be evaluated as an alternative to fixed-frequency 10Hz rTMS,
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Pilot Testing of Peak Alpha Frequency Stability During Repetitive Transcranial Magnetic Stimulation
Nicholas J. Petrosino, et al.
Fourteen (66.7%) participants showed meaningful clinical improvement on the PCL-5, and 11 (52.4%) showed a decrease to threshold for categorical PTSD response.
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Efficacy and Safety of Synchronized Transcranial Magnetic Stimulation (sTMS) for Treatment of Major Depression
Subjects who received sTMS per-protocol (N = 59) had significantly greater mean decrease in HamD17 scores after six weeks than those receiving sham treatment (N = 61) (-9.00 versus -6.56, p=0.033).
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Tuning out the Blues - Thalamo-Cortical Rhythms as a Successful Target for Treating Depression
In the case of psychiatric disorders, specific changes in the rhythmic activity structure of (thalamo-) cortical networks have been identified that correlate with behavioral and cognitive symptoms [3]. These pathological network dynamics represent a promising target for brain stimulation.
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Repetitive Transcranial Magnetic Stimulation (rTMS) in Treatment Resistant Depression: Retrospective Data Analysis from Clinical Practice
The results show that rTMS significantly improved all measures of depression and anxietyResponse and remission rates for depression were 34.6% and 20.6% for the HAM-D; 10% and 28.6% for the PHQ-9; 31% and 31.8% for the CGI; and for anxiety they were and 24.6% and 28.8% (GAD-7)
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Low-Field Synchronized Transcranial Magnetic Stimulation (sTMS) for Treatment of Depression: Results from an Open-label Extension Study
Mahendra T. Bhati, M.D., Michael E. Thase, M.D., Jonathan L. Bissett, B.S., Joseph M. Massaro, Ph.D., Andrew F. Leuchter, M.D.
sTMS is a safe and promising treatment for major depression. Sham-controlled and open-label data suggest that 20-30 treatments with sTMS alone may be beneficial for patients with depression and uniquely effective for treatment-resistant depression. sTMS offers a potential new form of TMS for treatment of depression.
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Pediatrics
Safety of Transcranial Magnetic Stimulation in Children: A Systematic Review of the Literature
Corey H Allen, BS, Benzi M Kluger, MD, MS, and Isabelle Buard, PhD
The risk of any adverse event during spTMS or ppTMS in healthy populations is 0.0342 (95% CI: 0.0223 - 0.0501) per session, 0.0597 (95% CI: 0.0447 - 0.0780) per session for patients with a CNS disorder, and 0.0455 (95% CI: 0.0125 - 0.1123) per session for those with epilepsy.
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A stable pattern of EEG spectral coherence distinguishes children with autism from neurotypical controls - a large case control study
Frank H Duffy and Heidelise Als
Classification success suggests a stable coherence loading pattern that differentiates ASD- from Cgroup subjects.
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A study on EEG feature extraction and classification in autistic children based on singular spectrum analysis method
Jie Zhao, Jiajia Song, Xiaoli Li, Jiannan Kang
When we used individualized alpha peak frequency (iAPF) and individualized alpha absolute power (iABP) as features for a linear support vector machine, ASD versus TD classification accuracy was 92.7%.
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Outcomes from Individual Alpha Frequency Guided Repetitive Transcranial Magnetic Stimulation in Children with Autism Spectrum Disorder – A Retrospective Chart Review
In conclusion, this study presents evidence on the efficacy and safety of α-rTMS in improving ASD symptoms, quality of life and comorbid sleep troubles in children.
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Addiction
Opioid withdrawal results in an increased local and remote functional connectivity at EEG alpha and beta frequency bands
Andrew A. Fingelkurts, Alexander A. Fingelkurts, Reetta Kivisaari, Taina Autti d, Sergei Borisov, Varpu Puuskari, Olga Jokela, Seppo Ka¨hko¨nen
The present study demonstrated significant increase in local and remote cortical functional connectivity in the opioiddependent patients during short-term withdrawal period, thus suggesting that increased inter-area communication among cortical areas may be one of the neurobiological underpinnings of the biased motivational and cognitive processes such as attention, emotions, and memories during withdrawal (see Drummond, 2001; Franken, 2003) supporting the removal of the aversive state behavior.
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Brain default-mode network dysfunction in addiction
Apart from this, DMN integrates information from various brain regions for self-related decisions and this function is impaired due to disrupted DMN connectivity to other large-scale networks.
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sTMS
Synchronized transcranial magnetic stimulation for posttraumatic stress disorder and comorbid major depression
All participants demonstrated significant reductions in PTSD and MDD symptoms (all p < .001). As expected, there were significant reductions in symptoms in both treatment groups, but active stimulation did provide greater reductions in count of PTSD moderate-to-severe symptoms
PDF
Electric Field Characteristics of Low-Field Synchronized Transcranial Magnetic Stimulation (sTMS)
Zhi-De Deng, Member, IEEE, and Sarah H. Lisanby
We found that the maximum induced electric field strength at the level of the cortex is approximately 0.02Vm 1, which is an order of magnitude lower compared to those delivered by transcranial current stimulation and low field magnetic stimulation.
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Low-Field Synchronized Transcranial Magnetic Stimulation (sTMS) for Treatment of Depression: Results from an Open-label Extension Study
Mahendra T. Bhati, M.D., Michael E. Thase, M.D., Jonathan L. Bissett, B.S., Joseph M. Massaro, Ph.D., Andrew F. Leuchter, M.D.
sTMS is a safe and promising treatment for major depression. Sham-controlled and open-label data suggest that 20-30 treatments with sTMS alone may be beneficial for patients with depression and uniquely effective for treatment-resistant depression. sTMS offers a potential new form of TMS for treatment of depression.
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